Extended Data Fig. 6: Antagonism differences between TSA and M9 + S do not affect depletion of on-person antagonism.
From: Intraspecies warfare restricts strain coexistence in human skin microbiomes
(a) We overlaid interactions from TSA onto the S. epidermidis interaction matrix generated in M9 + S media, using color to indicate which media the antagonism appeared in. In total, 91% of interactions are the same in both media conditions, though antagonisms did vary between the two media, such that 23% of antagonisms observed in TSA were also observed in M9 + S, and 61% of antagonisms observed in M9 + S were observed in TSA. (b-e) Despite these differences, we observed a significant depletion of on-person antagonism (ΔAF, see Fig. 3c, Methods) in permutation tests that compare our observed data compared to simulated data with shuffled lineage compositions on each participant. Significance P-values are derived from two-sided permutation tests with shuffled lineage labels (Methods), without multiple hypothesis correction.
