Extended Data Fig. 3: Antagonism and sensitivity generally cluster at the lineage level.

We measured 21,025 pairwise interactions between 145 isolates that passed inclusion criteria (15 replicate cultures were also included, totalling 25,600 interactions). The heatmap depicts the AUC of the ZOI calculated for pairwise interactions between S. epidermidis and other skin microbiome isolates in TSA. Each row and column indicate an isolate (in contrast to Fig. 2a where rows indicate lineages). Multiple isolates from a lineage are denoted by decimals (for example 20.1, 20.2, 20.3). Isolates are sorted by phylogenetic similarity, with dashed lines to indicate species boundaries. Each isolate of species other than S. epidermidis (labels > 200, see x-axis for details) was treated as a separate lineage. Interactions were shared among all isolates of the same lineage in ~97% of cases, so S. epidermidis isolates were dereplicated into lineages for other analyses unless otherwise noted. Nine isolates were added after the preliminary TSA screen, and thus are lacking some data points, indicated by brown squares. Unless otherwise noted, these isolates with partial data were excluded from statistical analysis.