Fig. 2: The VZV–host protein–protein interaction network in neuronal cells. | Nature Microbiology

Fig. 2: The VZV–host protein–protein interaction network in neuronal cells.

From: Multi-proteomic profiling of the varicella-zoster virus–host interface reveals host susceptibilities to severe infection

Fig. 2

a, Assembled network of the individual V5-tagged VZV protein–host interactomes generated by AP–MS in neuroblastoma SK-N-BE2 cells. VZV baits and host preys are shown as squares and ellipses, respectively (n = 4 independent experiments) (Supplementary Table 3). Viral proteins are numbered according to their gene name. The prey border colour specifies the enrichment factor; for preys targeted by several baits, the strongest enrichment is displayed. Host proteins selected for CRISPR–Cas9 knockout screen are highlighted in pink. b, Bar plots of GO Cellular Components enriched among the host proteins interacting with individual VZV proteins (one-sided Fisher’s exact test, unadjusted P ≤ 10−4). Actual −log10P values are indicated when truncated. Targeted GO Cellular Components were coloured according to parental cellular functions as defined in the legend.

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