Extended Data Fig. 1: High-temporal resolution gnotobiotic mice colonization and perturbation study using a dysbiotic human donor microbiome shows reproducible differential responses to perturbations.
From: Learning ecosystem-scale dynamics from microbiome data with MDSINE2
(a) Experimental design for the dysbiotic cohort (n = 5 mice) with an average of 76 serial fecal samples/mouse. (b) Average total bacterial concentrations in serial fecal samples. (c) Legend and taxonomy for panels d and e along with significant differential abundances (p < 0.05 for two-sided Wald test with BH correction) for each taxonomic group across the three perturbations (see Supplementary Data Table for p-values). (d) Relative abundance of microbes in human donor sample. (e) Relative abundances of microbes in serial fecal samples, averaged over the biological replicates. (f) Relative abundances of the top 100 most abundant ASVs across all mouse samples.
