Extended Data Fig. 4: HIV infection leads to the induction of the transcriptomic pattern of quiescence.
From: HIV infection reprogrammes CD4+ T cells for quiescence and entry into proviral latency
a. HIV infection leads to changes in gene expression that is characteristics of quiescent cells. The column to the left reflects the expected pattern of change in genes that constitute the molecular signature of quiescence. b. The pattern of change in gene expression after HIV infection closely resembles that following entry into quiescence in hematopoietic stem cells (lane labeled GSE24739, see Methods). c. Pattern of gene expression change after entry of HIV infected cells into full quiescence closely resembles that observed during quiescence in other cell types, as reflected in the quiescence signature pathways in mSigDB. Genes expected to be up or downregulated in quiescence are shown in the lane marked mSigDB with pink and light blue color, respectively.
