Extended Data Fig. 2: Validation of digital PCR assays and longitudinal quantification of defective proviruses during periods of suboptimal ART. | Nature Microbiology

Extended Data Fig. 2: Validation of digital PCR assays and longitudinal quantification of defective proviruses during periods of suboptimal ART.

From: Superinfection promotes replication and diversification of defective HIV-1 proviruses in people with non-suppressible viraemia

Extended Data Fig. 2

(a) Results of dPCR reaction using primer and probe sets to specifically amplify deletion regions of interest in 4 PWH on ART (040, 012, 017, and 274), P1, and P2. Horizontal bars represent mean and error bars represent SD, with each experiment performed in technical triplicate (n = 3). (b) Extended clinical history of P2 from Extended Data Fig. 1a (c) Longitudinal quantification of proviruses with specific deletion of interest using deletion-specific dPCR assay outlined in Fig. 3. WBCs: white blood cells (d) Longitudinal quantification of plasma virus with specific deletion of interest.

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