Extended Data Table 1 Evolutionary analysis, related to Fig. 2

From: The IFIT2–IFIT3 antiviral complex targets short 5’ untranslated regions on viral mRNAs for translation inhibition

  1. Evolutionary analyses on subdomains of rodent and primate IFIT2 and IFIT3. Statistical evidence for positive selection, determined by PAML software, is shown for each gene and each subdomain, with statistically significant p-values shown in bold red text. The p-value reported is the result of a chi-squared test on twice the difference of the log likelihood (lnL) values between the two PAML models of selection (M7 and M8) using two degrees of freedom. Overall dN/dS (omega) values for each subdomain are also shown. The number of specific codons within each subdomain that show statistical evidence for positive and negative selection, as determined by PAML and FUBAR software as indicated. Additional statistics and analysis parameters, complete lists of codons, and accession numbers and species of sequences analyzed are found in Supplementary Table 2.