Extended Data Fig. 8: Plasma EVs did not demonstrate detectable SARS-CoV-2 protein.
From: Liposome-mediated detection of SARS-CoV-2 RNA-positive extracellular vesicles in plasma
a. Proteomic analysis of plasma exosomes isolated from 3 patients with COVID-19 and 3 healthy donors who were diagnosed by nasal swab RT-qPCR. Numbers indicated the number of EV proteins identified by mass spectrometry from healthy donors and COVID-19 patients, and their overlap when detected peptides were searched against the UniProtKB protein database. No SARS-CoV-2 proteins were identified in this search. b. Western blot analysis of SARS-CoV-2 N protein expression in protein lysates (50 µg/lane) of plasma EVs isolated from three patients with COVID-19 (A1-A3). Positive control (PC), 10 µg SARS-CoV-2 recombinant protein; Negative control (NC), 50 µg EVs isolated from healthy donor plasma.
