Fig. 4: SARS-CoV-2 RNA expression time course in plasma EVs.
From: Liposome-mediated detection of SARS-CoV-2 RNA-positive extracellular vesicles in plasma
a, Normalized CRISPR-FDS liposome signal intensity from four NHP (African green monkeys, AG1–4) plasma samples and RT–PCR–CRISPR signal intensity from AG1–AG4 nasal swab samples at the indicated time points. Normalized intensity indicates fold-change versus the baseline mean value. b–d, Positive (red) and negative (blue) results for CRISPR-FDS liposome (EV) fluorescence intensity and results of nasal RT–qPCR and serological (IgG) analyses for three children at the indicated time points after first evaluation. The data represent the mean ± s.d. of three replicates.
