Extended Data Fig. 5: High frame rate optical imaging of GVs attached to tumour cells.
From: Acoustically triggered mechanotherapy using genetically encoded gas vesicles
(a) GVs attached to U87 cells (0.4 µs) are collapsed by the ultrasound wave (0.8 µs). (b) Differential map comparing pre- and post-collapse images (c) Only after the collapse of the GVs are cavitation events seen (3.4 µs and 9.2 µs). The samples were insonated with a single 30-cycle pulse with PNP = 1.4 MPa a central frequency of 670 kHz. The representative result in panels a-c belongs to one of the 8 repeats presented in Fig. 3g. Scale bars represent 20 µm (a-c).
