Extended Data Fig. 1: Comparison of UC therapy between BL@B-SA50 and clinical therapy.
(a) C57BL/6 mice were provided with water or 3% DSS-containing water for 4 days. On days 4, 5, 6 and 7, mice were orally administered with Medium, 5-ASA (30 mg kg–1), DEX (1 mg/kg), MPS (1 mg/kg) or BL@B-SA50 (BL: 2.5 × 108 CFU kg–1, B-SA: 1.25 mg/kg). (b) Daily body weight changes in each group for 9 days. Data were normalized as a percentage of the body weight at day 0. (c) Changes in DAI. (d) Lengths and (e) pictures of mice colon with indicated treatments on day 8. (f) C57BL/6 mice were provided with water or 3% DSS-containing water for 4 days. On days 4, 5, 6 and 7, mice were orally administered with Medium, BL (2.5 × 108 CFU/kg) + 5-ASA (30 mg/kg), BL (2.5 × 108 CFU/kg) + DEX (1 mg/kg), BL (2.5 × 108 CFU/kg) + MPS (1 mg/kg) or BL@B-SA50 (BL: 2.5 × 108 CFU/kg, B-SA: 1.25 mg/kg). (g) Daily body weight changes in each group for 9 days. Data were normalized as a percentage of the body weight at day 0. (h) Changes in DAI. (i) Lengths and (j) pictures of mice colon with indicated treatments on day 8. Data are presented as mean ± s. d. from n = 5 biological replicates. Statistical analysis was calculated by unpaired Student’s two-sided t test. 1P, 2P, 3P, 4P and 5P, in (b, c) denote the statistical significance of Health, BL@B-SA50, MPS, DEX and 5-ASA group relative to the Control group, while in (g, h) denotes the statistical significance of Health, BL@B-SA50, BL + MPS, BL + DEX and BL + 5-ASA group relative to the Control group, respectively. P in (d, i) denotes the statistical significance relative to the Control group. #P in (d, i) denotes the statistical significance of BL@B-SA50 relative to the Health group.
