Extended Data Fig. 7: The effects of Nor-PC and Cho-PC on cytotoxicity and immune response of macrophages to NPs.
(a-b) Cytotoxicity of AuNPs (a) and SNPs (b) with various coatings on Raw264.7 cells at 24 h. The data are presented as mean ± standard deviation with n = 3 (biologically independent experiments). Statistical significance was tested with a two-tailed, unpaired Student’s t-test. (c-d) Volcano plots of the protein expression change for the Nor-PC group (c) and Nor-PC group (d) versus the control group. (e) The overlap of the significantly changed proteins in the Cho-PC group and Nor-PC group versus the control group. (f) The enriched biological pathway of down-regulated proteins in the Nor-PC group and Cho-PC group by GO analysis.
