Fig. 4: Interaction of the origami with breast cancer cells and induction of DR5 clustering. | Nature Nanotechnology

Fig. 4: Interaction of the origami with breast cancer cells and induction of DR5 clustering.

From: A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns

Fig. 4

a, Experimental setup of cancer cell treatment with Cy5-labelled origami at pH 7.4 or 6.5. b, The Cy5 signal of SK-BR-3 cells treated with 5 nM empty origami, PEG_pH_O6p at pH 7.4 or 6.5, measured by flow cytometry. c, Localization of Cy5-labelled origamis (magenta) relative to DR5 (cyan; detected using Alexa488-labelled anti-DR5 monoclonal antibody) on SK-BR-3 cells. The co-localization of the magenta and cyan is shown in grey. Maximum intensity projections from z-stacks. Scale bars, 20 μm.

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