Fig. 6: In vivo biodistribution and anti-tumour effects.
From: A DNA robotic switch with regulated autonomous display of cytotoxic ligand nanopatterns
a, Biodistribution imaging after i.v. injection with Alexa750-labelled PEG_pH_O6p origami in nude mouse bearing a SK-BR-3 tumour at different timepoints. The tumour is indicated using a dashed circle. b, Imaging after i.t. injection with Alexa750-labelled PEG_pH_O6p origami in nude mouse bearing a SK-BR-3 tumour at different timepoints. The tumour is indicated using a dashed circle. c, Treatment schedule and SK-BR-3 tumour growth curves of mice receiving i.v. injections of PBS (n = 2), PEG_mutated_O6p (non-switchable control; n = 4) or PEG_pH_O6p (n = 4). d, Treatment schedule and SK-BR-3 tumour growth curves of mice receiving i.t. injections of PBS (n = 2), PEG_mutated_O6p (n = 4) or PEG_pH_O6p (n = 4). Statistical analysis was performed with one-way ANOVA followed by Tukey post-tests. Data are presented as mean ± s.d.
