Extended Data Fig. 1: Biocompatibility of cationic polypeptide in CIA rats. | Nature Nanotechnology

Extended Data Fig. 1: Biocompatibility of cationic polypeptide in CIA rats.

From: Synthetic polypeptides inhibit nucleic acid-induced inflammation in autoimmune diseases by disrupting multivalent TLR9 binding to LL37-DNA bundles

Extended Data Fig. 1

Systemic toxicity of cationic polypeptide. (a) H&E staining of heart, liver, spleen, lung and kidney samples extracted from normal rats, PBS, PEG-TK-LArg and PEG-TK-NPArg treated CIA rats with established-stage arthritis (the scale bar is 200 μm). (b) ALP, ALT, AST, creatinine, and BUN analysis of established-stage CIA rats at day 29 (n = 3 biologically independent samples). The dash line area is the normal range. The normal ranges of ALP, ALT, and AST are 84 ~ 162, 34.6 ~ 64.0 and 96 ~ 200 U/L, respectively. The normal ranges of creatinine and BUN levels in rat serum are 44.2 ~ 114.9 μmol/L and 9.73 ~ 14.53 mmol/L, respectively. All the quantitative data are presented as mean ± s.d.

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