Extended Data Fig. 6: In vivo aNP-induced LAMP1 knockdown effect in splenic myeloid cells. | Nature Nanotechnology

Extended Data Fig. 6: In vivo aNP-induced LAMP1 knockdown effect in splenic myeloid cells.

From: Nature-inspired platform nanotechnology for RNA delivery to myeloid cells and their bone marrow progenitors

Extended Data Fig. 6

Relative LAMP1 expression levels measured by flow cytometry in various cell populations in the bone marrow among which leukocytes, myeloid cells, dendritic cells, macrophages, monocytes, monocytes Ly6C high, neutrophils & monocytes Ly6C low. The gating strategy is displayed in Supplementary Fig. 4b. Data represent mean ± SD of one experiment (n = 6 animals) and analyzed by one-way ANOVA with Bonferroni post-hoc test. Statistically significant differences between aNP-siLAMP1 versus aNP-siCtrl formulations are indicated by: * indicates statistical significance (p ≤ 0.05), ** indicates statistical significance (p ≤ 0.01), *** indicates statistical significance (p ≤ 0.001), **** indicates statistical significance (p ≤ 0.0001).

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