Extended Data Fig. 5: Overlaid nanopore current traces and two-dimensional current intensity plots from the first 100 linear events recorded for E. coli carriers interacting with the fully complementary E. coli nanolatch (a) and the mismatched S. Typhi nanolatch (b).

The orange circle refers to the latched loop formed on the E. coli carrier with the fully complementary E. coli nanolatch, while the short orange line refers to the sensing overhang in the absence of loop formation when using the mismatched S. Typhi nanolatch.