Extended Data Fig. 5: Rat brain electrophysiological dose-response analyses of Ketamine HCl i.v. infusion. | Nature Nanotechnology

Extended Data Fig. 5: Rat brain electrophysiological dose-response analyses of Ketamine HCl i.v. infusion.

From: Acoustically activatable liposomes as a translational nanotechnology for site-targeted drug delivery and noninvasive neuromodulation

Extended Data Fig. 5

a. Non-normalized time-frequency spectrograms of unencapsulated ketamine dose response recording from mPFC (top row) and RsC (bottom row) following 0.5, 0.75, 1, and 1.5 mg/kg i.v. infusion. b. Spectrograms of power percent change from the baseline (0-5 minutes of the recording). c. Percent power change from baseline (0-5 min) versus frequency (Hz). Percent change was averaged within time bins during sonication (7.5-10 min), immediately after treatment (10-25 min), and after the clearance time point (25-45 min).

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