Extended Data Table 1 Typical physicochemical characterization of the presented drug-loaded liposomes
Formulation | Average Size (nm) | PDI | Zeta Potential (mV) | Drug Loading (mg/mL) | Free Drug (%) | Entrapment Efficiency (%) | pKa | LogP |
|---|---|---|---|---|---|---|---|---|
Ketamine Liposome (KL) | 7.5 | 2.2 | ||||||
KL | 164.07 ± 6.5 | 0.06 ± 0.02 | -45.2 | 3.19 ± 0.17 | 4.96 ± 0.80 | 24-27 |  |  |
S5-KL a.k.a. SonoKet | 158.06 ± 5.5 | 0.08 ± 0.01 | -46.3 | 3.41 ± 0.24 | 3.09 ± 1.38 | 25-29 |  |  |
S10-KL | 160.86 ± 6.0 | 0.06 ± 0.03 | -44.9 | 3.27 ± 0.21 | 3.59 ± 2.02 | 25-28 |  |  |
NaCl5-KL | 160.36 ± 7.0 | 0.06 ± 0.02 | -48.7 | 3.21 ± 0.14 | 4.62 ± 2.16 | 25-27 |  |  |
Glu5-KL | 157.86 ± 7.0 | 0.09 ± 0.01 | -47.7 | 3.24 ± 0.20 | 3.24 ± 2.42 | 24-28 |  |  |
Lidocaine Liposome (LL) | 8.0 | 2.3 | ||||||
LL | 159.90 ± 2.5 | 0.06 ± 0.01 | -49.5 | 4.61 ± 0.07 | 1.82 ± 0.32 | 36-39 |  |  |
S5-LL | 161.10 ± 2.1 | 0.06 ± 0.02 | -49.1 | 4.50 ± 0.14 | 1.45 ± 0.45 | 36-40 |  |  |
Bupivacaine Liposome (BL) | 8.1 | 3.4 | ||||||
BL | 165.80 ± 3.2 | 0.09 ± 0.01 | -55.4 | 5.60 ± 0.09 | 3.86 ± 1.02 | 39-42 |  |  |
S5-BL | 164.38 ± 3.6 | 0.06 ± 0.03 | -49.2 | 5.81 ± 0.12 | 4.02 ± 3.02 | 39-44 |  |  |
Ropivacaine Liposome (RL) | 8.1 | 2.9 | ||||||
RL | 169.73 ± 3.2 | 0.07 ± 0.02 | -43.3 | 4.32 ± 0.35 | 3.81 ± 2.12 | 38-43 |  |  |
S5-RL a.k.a. SonoRopi | 166.71 ± 3.8 | 0.08 ± 0.01 | -49.2 | 4.51 ± 0.42 | 4.85 ± 1.07 | 37-41 |  |  |
