Extended Data Table 1 Typical physicochemical characterization of the presented drug-loaded liposomes

From: Acoustically activatable liposomes as a translational nanotechnology for site-targeted drug delivery and noninvasive neuromodulation

Formulation

Average Size (nm)

PDI

Zeta Potential (mV)

Drug Loading (mg/mL)

Free Drug (%)

Entrapment Efficiency (%)

pKa

LogP

Ketamine Liposome (KL)

7.5

2.2

KL

164.07 ± 6.5

0.06 ± 0.02

-45.2

3.19 ± 0.17

4.96 ± 0.80

24-27

  

S5-KL a.k.a.

SonoKet

158.06 ± 5.5

0.08 ± 0.01

-46.3

3.41 ± 0.24

3.09 ± 1.38

25-29

  

S10-KL

160.86 ± 6.0

0.06 ± 0.03

-44.9

3.27 ± 0.21

3.59 ± 2.02

25-28

  

NaCl5-KL

160.36 ± 7.0

0.06 ± 0.02

-48.7

3.21 ± 0.14

4.62 ± 2.16

25-27

  

Glu5-KL

157.86 ± 7.0

0.09 ± 0.01

-47.7

3.24 ± 0.20

3.24 ± 2.42

24-28

  

Lidocaine Liposome (LL)

8.0

2.3

LL

159.90 ± 2.5

0.06 ± 0.01

-49.5

4.61 ± 0.07

1.82 ± 0.32

36-39

  

S5-LL

161.10 ± 2.1

0.06 ± 0.02

-49.1

4.50 ± 0.14

1.45 ± 0.45

36-40

  

Bupivacaine Liposome (BL)

8.1

3.4

BL

165.80 ± 3.2

0.09 ± 0.01

-55.4

5.60 ± 0.09

3.86 ± 1.02

39-42

  

S5-BL

164.38 ± 3.6

0.06 ± 0.03

-49.2

5.81 ± 0.12

4.02 ± 3.02

39-44

  

Ropivacaine Liposome (RL)

8.1

2.9

RL

169.73 ± 3.2

0.07 ± 0.02

-43.3

4.32 ± 0.35

3.81 ± 2.12

38-43

  

S5-RL a.k.a.

SonoRopi

166.71 ± 3.8

0.08 ± 0.01

-49.2

4.51 ± 0.42

4.85 ± 1.07

37-41

  
  1. Note: S5 = 5% additional sucrose, S10 = 10% additional sucrose in the internal buffer of the liposome. The pKa and logP values were derived from PubChem and DrugBank.