Extended Data Table 4 Pharmacokinetic analysis of ketamine and its metabolites following ketamine-loaded AAL or free ketamine 1.5 mg/kg over 5 min intravenous infusion

C_max

ng/mL

381.60 ± 56.44

270.16 ± 38.97

0.164

T_max

m

5 ± 0

5 ± 0

NA

t_1/2

m

16.33 ± 0.99

17.00 ± 3.97

0.851

AUC_0-t

ng/mL m

4416.27 ± 592.34

4098.46 ± 246.48

0.585

AUC_0-∞ (obs)

ng/mL m

6847.83 ± 13.09.70

7116.36 ± 1027.23

0.842

MRT_0-t

m

8.29 ± 0.05

9.47 ± 0.26

0.089

MRT_0-∞ (obs)

m

21.14 ± 1.23

24.56 ± 5.65

0.544

VZ (obs)

L

1.25 ± 0.10

1.37 ± 0.33

0.700

Cl

L/m

0.053 ± 0.007

0.056 ± 0.001

0.713

VSS (obs)

L

1.143 ± 0.059

1.42 ± 0.406

0.510

C_max

ng/mL

141.59 ± 19.37

106.76 ± 9.82

0.078

T_max

m

5 ± 0

15 ± 14.14

0.500

t_1/2

m

28.33 ± 6.66

NA

NA

AUC_0-t

ng/mL m

2365.84 ± 188.01

1898.10 ± 2.51

0.127

MRT_0-t

m

9.98 ± 0.41

10.83 ± 1.16

0.482