Extended Data Fig. 8: Average largest cluster sizes obtained from the Independent and the Cell Cycle Timer models with differential growth.

Left panel: final size of the largest cluster as a fraction of total cell number for the Independent model with differential growth, averaged over 2,200 simulation runs, as a function of the ratio of division probability weights for the fast and slow-growing cell populations, \(w_{{{\mathrm{f}}}}/w_{{{\mathrm{s}}}}\), and the probability of each starting cluster being assigned to the fast-growing population, \(p_{{{\mathrm{f}}}}\). Cyan-bordered region in both panels shows where theoretical and experimental values of the final largest cluster fraction are less than an experimental standard deviation apart (experimental value average over all chambers with >600 cells: largest cluster size fraction = 0.36, s.d. = 0.06, n = 7; Supplementary Table 3). Right panel: final size of the largest cluster as a fraction of total cell number for the Cell Cycle Timer differential growth model for \(t_{{{\mathrm{s}}}}\) = 9.6 h and \(\sigma _{{{\mathrm{s}}}} = \sigma _{{{\mathrm{f}}}} = 0.5\) h, averaged over 2,200 simulation runs, as a function of the mean division time ratio between the fast and slow cell populations, \(t_{{{\mathrm{f}}}}/t_{{{\mathrm{s}}}}\), and the probability of each starting cluster being assigned to the fast population, \(p_{{{\mathrm{f}}}}\).