Fig. 3: Radiobiological pilot study and follow up (reference proton data (cyclotron at UPTD) in green; LPA proton data (Draco PW) in blue).
From: Tumour irradiation in mice with a laser-accelerated proton beam
a, Examples of irradiation timescales; the continuous irradiation of the UPTD cyclotron is indicated in green and pulsed irradiation of three selected mice at Draco PW, in blue. The inset shows a rapid dose application by the LPA proton bunch. b, Proton tumour doses of all the mice including 2σ uncertainties at the cyclotron (\({D}_{{{{\rm{PTV}}}}}^{{{{\rm{UPTD}}}}}\)) and laser accelerator (\({D}_{{{{\rm{PTV}}}}}^{{{{\rm{Draco}}}}}\)). The final dose values at Draco PW as the weighted mean of two independent absolute dosimetry methods (IC and dRCF; light blue). The mean values for all the animals are given by dashed lines. c,d, Individual tumour growth curves as the relative tumour volume increases after allocation/treatment for growth control (light grey), sham (dark grey) and proton-irradiated (green/blue) mice at the respective facilities. Tumour growth of the sham-treated groups, which run in parallel to the irradiated ones, indicate the influence of the respective treatment conditions. Unaffected tumour growth is shown by the control mice that remain in the corresponding animal facilities. The asterisks indicate mice with fast-growing secondary tumours, and the plus signs indicates tumour volume reduction due to scabbing. The number of animals per group is given in the parentheses. The x axis is interrupted to display a longer period of time with no substantial change in tumour volume.
