Fig. 4: Tissue fluidization at high contractility/tension by cell cycle-dependent cell area dynamics.
From: Cell cycle dynamics control fluidity of the developing mouse neuroepithelium
a,b, T1 rate (a) and mean cell area CV (b) for simulations with different modes of cell area increase during the cell cycle and different levels of noise (σ) as indicated. N/A indicates no division; IKNM, cell cycle-dependent target area; linear, linear area increase; linear + A0 noise, linear area increase with A0 noise; exp nλ, exponential increase with rate nλ, where n is indicated (Methods). Error bars, standard deviation from ten simulations per condition. Region C (\({{{\bar{\varLambda }}}}\) = −0.074, \({{{\bar{\varGamma}}}}\) = 0.12). Double-sided t-tests for all conditions compared with the default: P < 0.0001. c, Apical area of 200 randomly selected individual cells in simulations with conditions: IKNM with σ = 0.02 (left); linear with σ = 0.02 (middle). The mean cell area during the cell cycle (normalized to the maximum) is shown in c (right) for the indicated conditions with σ = 0.02; sample sizes (number of cells), IKNM (n = 4,625); linear (n = 3,880); linear + A0 noise (n = 3,984); exp 4λ (n = 12,725). The cell cycle time is normalized from cell birth to cell division (end of mitosis). Error bars, standard deviation.
