Extended Data Fig. 10: Velocity dependency on friction anisotropy.
From: Emergence of bidirectional cell laning from collective contact guidance
The experimental evolution of the velocity with respect to groove depth (a) is well captured by the corresponding simulations (C, ks = 6). Except for very small anisotropies, this value of the velocity-reinforcement (ks = 6) corresponds to the laning regime (see Fig. 4c) and therefore the continuum theory is not expected to quantitatively describe the experiments. Yet, it qualitatively gives the trend of evolution of the two components of the velocity vs groove depth for shallow grooves (b). By contrast, in the disordered regime, the theoretical evolution of the velocity with friction anisotropy in the disordered regime (panel B) accounts well for the corresponding simulation (panel C, ks = 3). Panel A: t = 20 h post confluence. Data are presented as mean values ± SD. Panel C: Parameters are listed in Supplementary Table 1.
