Fig. 5: Tumour growth.

a, Average tumour volumes calculated from 2D caliper measurements of the visible tumour (Methods) for the 0 Gy control group (n = 27 animals, purple line and circle symbols), 5 Gy group (n = 6 animals, light-blue line and square symbols) and 20 Gy group (n = 22 animals, orange line and triangle symbols). Over the course of observation period, 12 animals from the 0 Gy group had to be euthanized when the permitted tumour burden was reached. The vertical dashed line corresponds to the timepoint of irradiation. b, Measurements of the volumes using μCT. Data are more precise than caliper measurements, but they are less frequent than external measurements. c, Zoom of the data points for irradiated groups shows the recurrence of the tumour irradiated with 5 Gy. Bars are standard errors of the mean values of the different animals. For every type of tumour measurement data, a two-way analysis of variance was performed (GraphPad Prism version 10.5.0 (774)) to estimate the differences in the impact of different radiation doses on the tumour growth dynamics. All tests were two-sided, and effect sizes were not computed.