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Cancer treatment

Radioactive ion beams for radiotherapy

Radiotherapy with charged particles is highly sensitive to uncertainties in their range. Now, radioactive ion beams offer increased precision and real-time imaging for tumour control while maintaining low toxicity to organs at risk.

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Fig. 1: Treatment set-up and PET signal for both stable 12C and radioactive 11C beams.

References

  1. Bortfeld, T. Phys. Med. Biol. 51, R363–R379 (2006).

    Article  ADS  Google Scholar 

  2. Nutting, C., Dearnaley, D. P. & Webb, S. BJR 73, 459–469 (2000).

    Article  Google Scholar 

  3. Boscolo, D. et al. Nat. Phys. https://doi.org/10.1038/s41567-025-02993-8 (2025).

    Article  Google Scholar 

  4. Durante, M. & Paganetti, H. Rep. Prog. Phys. 79, 096702 (2016).

    Article  ADS  Google Scholar 

  5. Parodi, K. & Polf, J. C. Med. Phys. 45, e1036–e1050 (2018).

    Article  Google Scholar 

  6. Gerlach, S. et al. Phys. Med. Biol. 65, 245045 (2020).

    Article  Google Scholar 

  7. Castle, K. D. & Kirsch, D. G. Cancer Res. 79, 5685–5692 (2019).

    Article  Google Scholar 

Download references

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Correspondence to Michael K. Fix.

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Fix, M.K. Radioactive ion beams for radiotherapy. Nat. Phys. (2025). https://doi.org/10.1038/s41567-025-03038-w

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