A study using advanced single-cell technologies has broadened our understanding of the diversity and complexity of brain endothelial cells by uncovering new endothelial subtypes and transcriptional patterns. These findings offer insights into potential therapeutic targets and emphasize the need for further research on vascular lineages and neurovascular interactions.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$32.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Yang, A. C. et al. A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk. Nature 603, 885–892 (2022).
Winkler, E. A. et al. A single-cell atlas of the normal and malformed human brain vasculature. Science 375, eabi7377 (2022).
Crouch, E. E. et al. Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain. Cell 185, 3753–3769.e18 (2022).
Wälchli, T. et al. Single-cell atlas of the human brain vasculature across development, adulthood and disease. Nature 632, 603–613 (2024).
Vanlandewijck, M. et al. A molecular atlas of cell types and zonation in the brain vasculature. Nature 554, 475–480 (2018).
Arnold, T. D. et al. Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain. Development 141, 4489–4499 (2014).
Crouch, E. E., Liu, C., Silva-Vargas, V. & Doetsch, F. Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage. J. Neurosci. 35, 4528–4539 (2015).
Yucel, N. et al. Cardiac endothelial cells maintain open chromatin and expression of cardiomyocyte myofibrillar genes. eLife 9, e55730 (2020).
Scordo, M. et al. Results of a phase 1 open label dose escalation trial of AB-205 (allogeneic engineered endothelial cell therapy) in adults with lymphoma undergoing high-dose therapy and autologous hematopoietic cell transplantation (HDT-AHCT). Blood 136, 14–15 (2020).
Welti, J., Loges, S., Dimmeler, S. & Carmeliet, P. Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer. J. Clin. Invest 123, 3190–3200 (2013).
Acknowledgements
The author received grant support from the National Institutes of Health NINDS (K08 NS116161), NIMH (1DP2MH136391-01) and California Institute for Regenerative Medicine (DISC0-14392).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Crouch, E.E. The molecular landscape of vascular cells in the human brain. Nat Rev Cardiol 21, 847–848 (2024). https://doi.org/10.1038/s41569-024-01079-x
Published:
Issue date:
DOI: https://doi.org/10.1038/s41569-024-01079-x
