Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • In Brief
  • Published:

PAEDIATRIC CANCER

Outcomes depend on tumour histology

Nature Reviews Clinical Oncology volume 16, page 6 (2019)Cite this article

Subjects

Access through your institution
Buy or subscribe

In a phase III trial, children with newly diagnosed supratentorial primitive neuroectodermal tumour of the central nervous system (CNS-PNET) or pineoblastoma were randomly assigned to receive additional carboplatin during standard chemoradiotherapy after surgery, and subsequently to receive maintenance chemotherapy with or without adjuvant isotretinoin. Of 60 patients, 31 had tumours with a nonpineal location, 18 of which were high-grade gliomas (HGGs), not intended for trial inclusion. At 5 years, event-free survival was 62.8% for patients with CNS-PNETs or pineoblastoma and 5.6% for those with HGG, and overall survival was 78.5% and 12.0%, respectively. Survival outcomes were not significantly affected by therapy, which indicates that an accurate histological diagnosis is needed to spare children with HGG from receiving unnecessary treatments.

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

Original article

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Clinical Oncology http://www.nature.com/nrclinonc

    Diana Romero

Authors
  1. Diana Romero
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Diana Romero.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Romero, D. Outcomes depend on tumour histology. Nat Rev Clin Oncol 16, 6 (2019). https://doi.org/10.1038/s41571-018-0129-5

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41571-018-0129-5

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer