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PROSTATE CANCER

PSMA PET–CT improves staging

Nature Reviews Clinical Oncology volume 17, page 337 (2020)Cite this article

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The limited performance of conventional CT and bone scanning in detecting non-localized prostate cancer during primary staging can lead to suboptimal treatment. Now, evidence from the phase III proPSMA trial indicates that prostate-specific membrane antigen (PSMA) PET–CT is a superior staging modality.

In proPSMA, 302 men with biopsy-proven high-risk localized prostate cancer were randomly assigned (1:1) to first-line imaging with either gallium-68 PSMA-11 PET–CT or conventional single-photon emission CT plus technetium-99m bone scanning. The primary outcome of the trial was the accuracy of first-line imaging for identifying pelvic nodal or distant metastatic disease, as defined by the receiver-operating curve using a predefined reference standard comprising histopathology, imaging and biochemical analyses after a follow-up duration of 6 months.

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  1. Nature Reviews Clinical Oncology http://www.nature.com/nrclinonc

    David Killock

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  1. David Killock
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Correspondence to David Killock.

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Killock, D. PSMA PET–CT improves staging. Nat Rev Clin Oncol 17, 337 (2020). https://doi.org/10.1038/s41571-020-0364-4

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