Fig. 3: Overview of personalized risk reduction and breast cancer prevention paradigms.
From: Personalized early detection and prevention of breast cancer: ENVISION consensus statement
Various risk factors contribute to field defects in breast tissues that favour the development of breast cancer. The presence of such field defects can be assessed using biomarkers and/or imaging to guide personalized prevention strategies, the success of which can be monitored on an ongoing basis through intermediate surrogates (for example, reduction or resolution of the field defect) that reflect the ultimate goal of a decreased incidence of breast cancers with features indicative of a poor prognosis.
