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HAEMATOLOGICAL CANCER

Anti-CD7 CAR T cells for T-ALL: impressive early-stage efficacy

Nature Reviews Clinical Oncology volume 18, pages 677–678 (2021)Cite this article

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Chimeric antigen receptor (CAR) T cells have remarkable efficacy in patients with B cell acute lymphoblastic leukaemia (ALL), but have not been successful to date in patients with T cell ALL (T-ALL). Now, data from Pan and colleagues demonstrate the safety and impressive short-term efficacy of allogeneic donor-derived anti-CD7 CAR T cells in an early-phase clinical trial involving patients with relapsed and/or refractory T-ALL.

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Authors and Affiliations

  1. Department of Pediatrics, The Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    David T. Teachey & Stephen P. Hunger

  2. The Center for Childhood Cancer Research, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    David T. Teachey & Stephen P. Hunger

Authors
  1. David T. Teachey
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  2. Stephen P. Hunger
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Correspondence to Stephen P. Hunger.

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Competing interests

D.T.T. serves on the scientific advisory boards of BEAM Therapeutics, Janssen, La Roche and Sobi; receives research funding from Leukemia and Lymphoma Society and Neoimmune Tech; and has a patent pending on biomarkers for cytokine-release syndrome (US2018025272A1). S.P.H. owns stock in Amgen and has received honoraria for lectures from Amgen and Jazz.

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Teachey, D.T., Hunger, S.P. Anti-CD7 CAR T cells for T-ALL: impressive early-stage efficacy. Nat Rev Clin Oncol 18, 677–678 (2021). https://doi.org/10.1038/s41571-021-00556-3

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