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Adipocyte-derived exosomes drive cancer metastasis

Nature Reviews Endocrinology volume 18, page 68 (2022)Cite this article

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Obesity and type 2 diabetes mellitus (T2DM) are known to be linked with the risk of metastatic breast cancer. However, the molecular mechanisms underlying this association are not fully understood. Now, a new study in Science Signaling has uncovered a role for adipocyte-derived exosomes in breast cancer metastasis.

The researchers then compared the effect of exosomes derived from women with T2DM and those from women without T2DM. “We asked whether obesity-driven diabetes mellitus makes the tumours more dangerous,” explains corresponding author Gerald Denis. “We found that tumour cell models underwent gene expression changes associated with greater tissue invasiveness, metastatic potential and treatment resistance.” Similar results were seen in multiple tumour cell models, from both humans and mice.

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References

Original article

  • Jafari, N. et al. Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes. Sci. Signal. 14, eabj2807 (2021)

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  1. Nature Reviews Endocrinology http://www.nature.com/nrendo/

    Olivia Tysoe

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  1. Olivia Tysoe
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Correspondence to Olivia Tysoe.

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Tysoe, O. Adipocyte-derived exosomes drive cancer metastasis. Nat Rev Endocrinol 18, 68 (2022). https://doi.org/10.1038/s41574-021-00622-x

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  • DOI: https://doi.org/10.1038/s41574-021-00622-x

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