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Post-burn endocrine–immune dynamics and ageing considerations

Thermal injuries trigger stress-induced endocrine responses that are critical for survival. With age, these responses falter, which results in an inability to combat burn-induced dysfunction and greatly increased mortality. Current knowledge about the post-burn endocrine response in older adults is sparse, which leaves therapeutic gaps for this vulnerable and expanding demographic.

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Fig. 1: Immune and endocrine alterations in younger adult (<60 years old) and older adult (≥60 years old) patients with burn injuries.

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Correspondence to Marc G. Jeschke.

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Khalaf, F., Ricciuti, Z., Barayan, D. et al. Post-burn endocrine–immune dynamics and ageing considerations. Nat Rev Endocrinol 20, 567–568 (2024). https://doi.org/10.1038/s41574-024-01018-3

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