Advances in biomedical research often result from a straightforward formula: a good working hypothesis, a set of dedicated investigators, and access to calorimetric chambers and a laboratory scale. The success of this approach has again been demonstrated in a new Cell Metabolism report showing that tirzepatide induces weight loss through partially distinct mechanisms in mice and humans.
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Novikoff, A., Müller, T.D. Tirzepatide differentially affects body weight in mice and humans. Nat Rev Endocrinol 21, 462–463 (2025). https://doi.org/10.1038/s41574-025-01139-3
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DOI: https://doi.org/10.1038/s41574-025-01139-3
