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Two decades into the crosstalk between bone and energy metabolism

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Aside from a few days around Halloween, the skeleton tends not to have a positive image. However, at least in the biomedical field, this view is changing as bone is now identified as an endocrine organ that positively regulates a broad range of key functions, including several aspects of energy metabolism.

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Fig. 1: Schematic representation of the best understood endocrine regulators underlying the crosstalk between bone and energy metabolism.

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Correspondence to Patricia Ducy.

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Ducy, P. Two decades into the crosstalk between bone and energy metabolism. Nat Rev Endocrinol 21, 660–661 (2025). https://doi.org/10.1038/s41574-025-01179-9

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