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The long-overlooked effect of hypothyroidism on the global burden of non-communicable diseases

Nature Reviews Endocrinology (2026)Cite this article

This Comment highlights the multiple effects of hypothyroidism and its strong connection to non-communicable diseases (NCDs), serving as a call to action for a global alliance to recognize hypothyroidism as a modifiable risk factor for NCDs. Additionally, it emphasizes the urgent need to raise awareness and improve thyroid management to address the growing burden of NCDs.

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Fig. 1: The iceberg model of hypothyroidism.

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Authors and Affiliations

  1. Evgenideion Hospital, Unit of Endocrinology, Diabetes and Metabolism, National and Kapodistrian University of Athens, Athens, Greece

    Leonidas H. Duntas

  2. Division of Endocrinology, Diabetes and Metabolism, University Hospital of Lausanne and University of Lausanne, Lausanne, Switzerland

    Peter A. Kopp

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  1. Leonidas H. Duntas
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  2. Peter A. Kopp
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Correspondence to Leonidas H. Duntas.

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Duntas, L.H., Kopp, P.A. The long-overlooked effect of hypothyroidism on the global burden of non-communicable diseases. Nat Rev Endocrinol (2026). https://doi.org/10.1038/s41574-026-01235-y

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