Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Research Highlight
  • Published:

Clinical genetics

CHIPping away at the genetic aetiology of clonal haematopoiesis

Nature Reviews Genetics volume 24, page 69 (2023)Cite this article

Subjects

Access through your institution
Buy or subscribe

Reporting in Nature, Kessler et al. describe the use of exome sequencing to identify individuals with clonal haematopoiesis of indeterminate potential (CHIP), coupled with genetic association studies to discover new germline variants associated with particular CHIP subtypes and their links to particular health outcomes.

Focusing on 23 well-defined, CHIP-associated genes, the authors used exome-sequencing data from 454,803 individuals from the UK Biobank (UKB) and 173,585 individuals from the Geisinger MyCode Community Health Initiative (GHS) to identify 27,331 and 12,877 individuals, respectively, with CHIP mutation carrier status (having single or multiple CHIP gene-specific somatic mutations).

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

Original article

Related article

  • Silver, A. J., Bick, A. G. & Savona, M. R. Germline risk of clonal haematopoiesis. Nat. Rev. Genet. 22, 603–617 (2021)

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nature Reviews Genetics http://www.nature.com/nrg/

    Kirsty Minton

Authors
  1. Kirsty Minton
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Kirsty Minton.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Minton, K. CHIPping away at the genetic aetiology of clonal haematopoiesis. Nat Rev Genet 24, 69 (2023). https://doi.org/10.1038/s41576-022-00565-7

Download citation

  • Published:

  • Issue date:

  • DOI: https://doi.org/10.1038/s41576-022-00565-7

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing