The widespread use of medically assisted reproduction fosters the false impression that the underlying causes of male infertility are not important to know. However, to improve men’s reproductive and long-term health, as well as the health of their offspring, large-scale genetic studies are essential. Thus, reproductive genomics should be implemented in diagnostics as soon as possible.
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References
Kimmins, S. et al. Frequency, morbidity and equity - the case for increased research on male fertility. Nat. Rev. Urol. 21, 102–124 (2024).
Barratt, C. L. R. et al. A global approach to addressing the policy, research and social challenges of male reproductive health. Hum. Reprod. Open. 2021, hoab009 (2021).
Krausz, C. & Riera-Escamilla, A. Genetics of male infertility. Nat. Rev. Urol. 15, 369–384 (2018).
Houston, B. J. et al. A systematic review of the validated monogenic causes of human male infertility: 2020 update and a discussion of emerging gene-disease relationships. Hum. Reprod. Update 28, 15–29 (2021).
Oud, M. S. et al. A de novo paradigm for male infertility. Nat. Commun. 13, 154 (2022).
Nagirnaja, L. et al. Diverse monogenic subforms of human spermatogenic failure.Nat. Commun. 13, 7953 (2022).
Riera-Escamilla, A. et al. Large-scale analyses of the X chromosome in 2,354 infertile men discover recurrently affected genes associated with spermatogenic failure. Am. J. Hum. Genet. 109, 1458–1471 (2022).
Wyrwoll, M. J. et al. Improved phenotypic classification of male infertility to promote discovery of genetic causes. Nat. Rev. Urol. 21, 91–101 (2024).
Wyrwoll, M. J. et al. Genetic architecture of azoospermia-time to advance the standard of care. Eur. Urol. 83, 452–462 (2023).
Stallmeyer, B., Dicke, A.-K. & Tüttelmann, F. How exome sequencing improves the diagnostics and management of infertile men. Andrology https://doi.org/10.1111/andr.13728 (2024).
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Veltman, J.A., Tüttelmann, F. Why geneticists should care about male infertility. Nat Rev Genet 25, 823–824 (2024). https://doi.org/10.1038/s41576-024-00773-3
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DOI: https://doi.org/10.1038/s41576-024-00773-3
