Recent advances in single-cell profiling technologies now enable routine and scalable measurements of cis-regulatory element activity across diverse cell types, disease states and genetic backgrounds. It is time to coordinate a global effort to systematically map cis-regulatory element function at single-cell resolution.
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Acknowledgements
This work is supported by the National Research Foundation, Singapore, under its NRF Fellowship programme (T.S.; NRFF16-2024-0030) and NRF Investigatorship programme (J.W.S.; NRFI08-0022), and Genome Institute of Singapore, A*STAR.
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See, Y.X., Stuart, T. & Shin, J.W. Cis-regulatory elements at cellular resolution. Nat Rev Genet 26, 653–654 (2025). https://doi.org/10.1038/s41576-025-00882-7
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DOI: https://doi.org/10.1038/s41576-025-00882-7
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