Large-scale annotation efforts over the past two decades have identified regulatory regions and networks through functional genomics and evolutionary analyses. The challenge now will be to incorporate the many ‘heterogeneities’ of gene regulation — across cell types, developmental stages and individuals — into regulatory annotation based on new experimental and computational approaches.
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Kumar, S., Gerstein, M. Regulatory genome annotation. Nat Rev Genet 26, 661–662 (2025). https://doi.org/10.1038/s41576-025-00885-4
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DOI: https://doi.org/10.1038/s41576-025-00885-4
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