Deep learning models have made impressive strides in decoding the regulatory genome, but key challenges remain unsolved.
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Acknowledgements
We thank J. Ernst, S. Roy, D. Knowles, A. Kundaje and R. Singh for their helpful comments on this Comment.
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Tiwari, S., Karbalayghareh, A. & Leslie, C.S. Predicting the regulatory genome. Nat Rev Genet 26, 659–660 (2025). https://doi.org/10.1038/s41576-025-00887-2
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DOI: https://doi.org/10.1038/s41576-025-00887-2
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