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TUMOUR IMMUNITY

Joint effort needed

Nature Reviews Immunology volume 19, page 717 (2019)Cite this article

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Much of the research on cancer immunotherapy has focused on eliciting CD8+ T cells that kill cancer cells. But evidence is mounting that CD4+ T cells are also required and may be crucial determinants of a successful response to immunotherapy, as reported by Robert Schreiber and colleagues in Nature.

MHC class II tetramers generated with the mITGB1 peptide stained a significant subset of CD4+ tumour-infiltrating lymphocytes from mice bearing T3 tumours compared with control tetramers. The mITGB1-specific CD4+ T cells were only activated by mITGB1 and not wild-type ITGB1, and they had a T helper 1 cell phenotype.

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  1. Nature Reviews Immunology http://www.nature.com/nri/

    Lucy Bird

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  1. Lucy Bird
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Correspondence to Lucy Bird.

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Bird, L. Joint effort needed. Nat Rev Immunol 19, 717 (2019). https://doi.org/10.1038/s41577-019-0242-4

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