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COVID-19

Roles for eosinophils and basophils in COVID-19?

Nature Reviews Immunology volume 20, page 461 (2020)Cite this article

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In this preprint, Rodriguez et al. used mass cytometry and Olink to longitudinally profile immune cells and protein biomarkers in the blood of 39 patients with severe COVID-19 from acute infection to recovery. Partition-based graph abstraction identified IFNγ-induced CD62L+ eosinophils, which appeared 2–6 days after hospitalization. In addition, the authors highlight a correlation between IgG responses and circulating basophil numbers. Finally, integrating 148 plasma proteins and 63 immune cell populations in a multi-omics factor analysis identified potential cellular and plasma biomarkers of transition to recovery from severe COVID-19. This work supports further investigation into the role of eosinophils in lung hyperinflammation and the potential role of basophils in enhancing the humoral response to COVID-19.

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  1. Sinai Immunology Review Project, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Alexandra Tabachnikova & Steven T. Chen

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  1. Alexandra Tabachnikova
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  2. Steven T. Chen
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Correspondence to Alexandra Tabachnikova or Steven T. Chen.

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Tabachnikova, A., Chen, S.T. Roles for eosinophils and basophils in COVID-19?. Nat Rev Immunol 20, 461 (2020). https://doi.org/10.1038/s41577-020-0379-1

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