Fig. 1: Neutralizing antibodies directed against the SARS-CoV-2 spike protein.
From: Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses
a | Schematic representation of the main domains of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein. Arrows denote S1/S2 and S2′ protease cleavage sites. b | Different groups of neutralizing antibodies (nAbs) that target the S protein. Representative nAbs targeting the S1 N-terminal domain (NTD), S1 receptor-binding domain (RBD), and S2 stem helix (SH) and S2 fusion peptide (FP) regions are shown with the S protein depicted in the RBD ‘up’ conformation. c | RBD-directed nAbs can be divided into four main classes depending on the epitopes they target in the RBD of the S protein. For each class, one representative nAb bound to the RBD monomer is shown: class 1, CB6; class 2, LY-CoV555; class 3, S309; class 4, CR3022. CD, connector domain; CH, central helix; CT, cytoplasmic tail; HR, heptad repeat; SD, subdomain; TM, transmembrane domain.
