Table 3 Neutralizing antibodies targeting the S2 subunit of the spike protein
From: Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses
Antibodies | Binding epitope in S2 subunit | Mechanism of neutralization | Viruses neutralized | Refs. |
---|---|---|---|---|
S2P6 | S2 stem helix | Inhibits membrane fusion | Beta-CoVs (sarbecoviruses, merbecoviruses and embecoviruses) | |
CC40.8 | S2 stem helix | Inhibits membrane fusion | Beta-CoVs (sarbecoviruses, HCoV-HKU1) | |
WS6 | S2 stem helix | Inhibits membrane fusion | Beta-CoVs (sarbecoviruses) | |
COV44-79 | S2 fusion peptide | Inhibits membrane fusion | Alpha-CoVs and beta-CoVs (except MERS-CoV) | |
COV44-62, VN01H1, VP12E7, 76E1 | S2 fusion peptide | Inhibits membrane fusion | Alpha-CoVs and beta-CoVs | |
C77G12 | S2 fusion peptide | Inhibits membrane fusion | Beta-CoVs |