US spending in biomedicine has driven pre-eminence in academia, Nobel prizes, scientific training discovery, translation and healthcare. The associated USAID spend on global health programmes has worldwide impacts, including on the ongoing HIV eradication timeline. Current policy changes place this continued trajectory into doubt, with ramifications for international research collaborations, global health and pandemic preparedness.
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References
Gaind, N. How the NIH dominates the world’s health research — in charts. Nature https://doi.org/10.1038/d41586-025-00754-4 (2025).
Flier, J. S. Academia and industry: allocating credit for discovery and development of new therapies. J. Clin. Invest. 129, 2172–2174 (2019).
Kozlov, M., Garisto, D. & Ledford, H. ‘Devastating’ cuts to NIH grants by Trump’s team put on hold by US judge. Nature https://doi.org/10.1038/d41586-025-00436-1 (2025).
Molteni, M. & McFarling, U. L. Some NIH study sections will resume grant reviews, but final funding decisions are still in limbo. STAT News https://go.nature.com/4iFhiif (2025).
Roubein, R. S., Sun, L. H. & Johnson, C.Y. Trump’s firings strike the nation’s health agencies. The Washington Post https://go.nature.com/4hLePkT (2025).
Mervis, J. U.S. judge blocks NIH’s plan to slash overhead cost payments. Science https://doi.org/10.1126/science.z9w4wq3 (2025).
Bowman, E. Elon Musk says federal employees must either document their work — or lose their jobs. NPR https://go.nature.com/4hPO3YK (2025).
Huang, P. RFK says most vaccine advisers have conflicts of interest. A report shows they don’t. NPR https://go.nature.com/4hHNyji (2025).
Milman, O. Trump officials decimate climate protections and consider axing key greenhouse gas finding. The Guardian https://go.nature.com/4iFmpPt (2025).
Wu, K. J. CDC data are disappearing. The Atlantic https://go.nature.com/4l7oxRI (2025).
Goodman, B. Disrupted US vaccine meetings could threaten timelines, access and transparency around shots. CNN https://go.nature.com/4hONwGz (2025).
Kunzelman, M. Judge tells agencies to restore webpages and data removed after Trump’s executive order. The Independent https://go.nature.com/4222rr0 (2025).
Sun, L. H. CDC scientific report resumes publication after unprecedented pause. The Washington Post https://go.nature.com/4230D0Y (2025).
Shuham, M. CDC staff prohibited from co-authoring papers with World Health Organization personnel. Huffpost https://go.nature.com/4hImyjP (2025).
Lay, K. US shutdown of HIV/Aids funding ‘could lead to 500,000 deaths in South Africa’. The Guardian https://go.nature.com/4j5ofc8 (2025).
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D.M.A. has received honoraria for consultancies with AstraZeneca, Novavax, PfizerBioNtech and Oxford Immuotec. A.L.R. declares no competing interests.
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Altmann, D.M., Rasmussen, A.L. How to respond when biomedical science and global health is under existential threat. Nat Rev Immunol 25, 313–314 (2025). https://doi.org/10.1038/s41577-025-01166-1
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DOI: https://doi.org/10.1038/s41577-025-01166-1
