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MULTIPLE SCLEROSIS

Neurophysiological and olfactory biomarkers for multiple sclerosis

Nature Reviews Neurology volume 15, page 1 (2019)Cite this article

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Magnetoencephalography (MEG) measurements and olfactory biomarkers can provide insights into brain function and disease activity in multiple sclerosis (MS), according to two new papers published in Multiple Sclerosis Journal. In the first study, Deborah Schoonhoven and colleagues showed that slowing of neuronal activity, as measured by resting-state MEG, correlated with cognitive impairment in patients with MS. In the second study, Gabriel Bsteh and co-workers found that inflammation and neurodegeneration in MS were associated with specific impairments in olfactory function.

The study by Schoonhoven et al. included 83 patients with MS and 34 healthy controls. The participants underwent resting-state MEG, as well as a battery of neuropsychological tests that enabled the patients with MS to be differentiated into three subgroups: cognitively preserved, mildly cognitively impaired and cognitively impaired (CI).

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  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Heather Wood

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  1. Heather Wood
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Correspondence to Heather Wood.

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Wood, H. Neurophysiological and olfactory biomarkers for multiple sclerosis. Nat Rev Neurol 15, 1 (2019). https://doi.org/10.1038/s41582-018-0119-3

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