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HUNTINGTON DISEASE

T helper cells implicated in early Huntington disease

Nature Reviews Neurology volume 16, page 4 (2020)Cite this article

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The presymptomatic stage of Huntington disease (HD) is marked by an increased prevalence of T helper 17.1 (TH17.1) cells in the cerebrospinal fluid (CSF), according to a new study published in Annals of Neurology. The finding suggests that therapies that reduce T cell-driven inflammation could delay or prevent onset of the disease.

“Studies have demonstrated the expression of mutated huntingtin in cells of the immune system, where the protein has pro-inflammatory properties,” explains Finn Sellebjerg, who led the new study alongside Marina von Essen. “This observation has led several research groups to investigate the possibility of immune activation within the CNS in HD, and whether this activation is involved in the pathogenesis of the disease.”

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  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Sarah Lemprière

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  1. Sarah Lemprière
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Correspondence to Sarah Lemprière.

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Lemprière, S. T helper cells implicated in early Huntington disease. Nat Rev Neurol 16, 4 (2020). https://doi.org/10.1038/s41582-019-0297-7

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