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PARKINSON DISEASE

MicroRNAs — diagnostic markers in Parkinson disease?

Nature Reviews Neurology volume 16, page 65 (2020)Cite this article

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MicroRNA (miRNA) levels in the saliva and blood are altered in Parkinson disease (PD), two studies published in Movement Disorders have shown. The findings suggest that non-invasive miRNA-based tests could be used to diagnose PD and even different PD subtypes.

The first study, led by Hyman Schipper, followed on from previous work by the same group with a mouse model of PD, in which haem oxygenase 1 (HO1) is overexpressed. In this model, miR-153 and miR-223 — two miRNAs that regulate the expression of α-synuclein — are downregulated in the brain and the serum. Schipper and colleagues investigated whether these miRNAs could serve as diagnostic biomarkers of PD.

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  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Ian Fyfe

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  1. Ian Fyfe
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Correspondence to Ian Fyfe.

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Fyfe, I. MicroRNAs — diagnostic markers in Parkinson disease?. Nat Rev Neurol 16, 65 (2020). https://doi.org/10.1038/s41582-019-0305-y

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