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NEURODEGENERATIVE DISEASE

α-Synuclein strains induce distinct diseases in mice

Nature Reviews Neurology volume 16, page 66 (2020)Cite this article

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Different strains of misfolded α-synuclein (α-syn) can cause clinically and pathologically distinct diseases in mice, according to a new study published in Nature Neuroscience. The findings highlight similarities between synucleinopathies and prion disease.

Synucleinopathies are neurodegenerative diseases that are characterized by the misfolding and aggregation of α-syn in the brain. These diseases have different clinical and pathological features, although the reasons for the differences are unclear.

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  1. Nature Reviews Neurology http://www.nature.com/nrneurol/

    Sarah Lemprière

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  1. Sarah Lemprière
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Correspondence to Sarah Lemprière.

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Lemprière, S. α-Synuclein strains induce distinct diseases in mice. Nat Rev Neurol 16, 66 (2020). https://doi.org/10.1038/s41582-019-0306-x

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